Parse the TWOSIDES Drug-Drug Interaction Database

Reads the TWOSIDES data file, which contains adverse event data for pairs of drugs taken concurrently (N=2 interactions).

Usage

parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)

Arguments

twosides_file_path

Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz').

db_version

used twoside version (default = NULL)

db_exported_date

used twoside release date (default = NULL)

Value

A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` data frame and associated metadata.

Details

TWOSIDES is a database of drug-drug interaction safety signals mined from the FDA's Adverse Event Reporting System using the same approach as is used to generate OffSIDES.

Database fields as follow:

drug_1_rxnorn_id

RxNORM identifier for drug 1

drug_1_concept_name

RxNORM name string for drug 1

drug_2_rxnorm_id

RxNORM identifier for drug 2

drug_2_concept_name

RxNORM name string for drug 3

condition_meddra_id

MedDRA identifier for the side effect

condition_concpet_name

MedDRA name string for the side effect

A

The number of reports for the pair of drugs that report the side effect

B

The number of reports for the pair of drugs that do not report the side effect

C

The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect

D

The number of reports for other PSM matched drugs and other side effects

PRR

Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))

PRR_error

Error estimate of the PRR

mean_reporting_frequency

Proportion of reports for the drug that report the side effect, A/(A+B)

See also

Other parsers: cett_nodes_options(), drug_node_options(), parseDrugBank(), parseOnSIDES(), references_node_options()